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According to investigators, that p53 participate in this process was a possibility. When scientists examined the gene for POMC that promotes production of the protein, they discovered that corresponded to p53, suggesting that when p53 fit into this location was accelerating the production of POMC. Furthermore, when the researchers exposed human and animal keratinocytes to ultraviolet radiation, after six hours, the levels of both POMC and p53 were much higher than normal and alpha-MSH were higher by 30 times than usual.
Subsequent studies provided further data on the involvement of p53 in the darkening of the skin. When the researchers included p53 in keratinocytes, POMC levels rose prominently. In addition, when using ultraviolet radiation in keratinocytes lacked p53, POMC production was not produced and the skin do not tan. (more…)